Abstract
Objective. To study the influence of normal vaginal microbiota on papillomavirus (HPV) infection. Patients and methods. We examined 160 women with HPV infection. We assessed the state of normal flora, the presence of sexually transmitted infections (STIs), and the HPV elimination rate. The correlation of living, apoptotic and necrotic epithelial cells depending on the levels of lactobacilli in native and stress-influenced specimens was studied in 140 HPV-positive and 20 HPV-negative patients. Results. We have found a stronger relation between HPV viral load and deficiency of lactobacilli (r = 0.498; р = 0.021) than between the former and the presence of STIs (r = 0.121; р = 0.072). High baseline levels of vaginal lactobacilli increase the likelihood of HPV elimination. Normal levels of lactobacilli enhance the survival of noninfected epithelial cells and reduce the levels of infected ones, which ensures a predominantly apoptotic form of cell death. HPV enhances the survival of infected cells and shifts the cell death structure toward necrosis. Conclusion. Lactobacilli counteract the influence of HPV on the vital conditions of vaginal epithelial cells. This accounts for better outcomes of HPV infection in patients with normal levels of flora. Key words: apoptosis, human papillomavirus, vagina, lactobacilli, cervix, epithelial cells
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