Abstract
This study investigated the anti-obesity effect of soybean fermented with Monascus. After inducing obesity by feeding high-fat diet using C57BL/6J mice for 4 weeks, a total of 46 rats were divided into 6 groups. Weight gain, dietary efficiency, fat tissue weight change, blood biochemical change, and histological change were analyzed by ingestion of soybean fermented with Monascus (UPSM_L, UPSM_H) and soybean (UPS) extract. The weight change in the UPSM_L and UPSM_H group was higher than that in the normal group, but was lower than that in the UPS group. The results of changes in heart, liver, kidney, peritoneal, epididymal and mesentric fat, cardiac hypertrophy and heart failure of high-fat group (HF) were significantly higher than those in Nor, UPS, UPSM_L and UPSM_H groups. The UPSM_H group showed a statistically significant decrease in the weight of kidney, mesenteric fat, and epididymal fat compared to the UPS group (p<0.05). Biochemical analyses showed that the concentration of serum triglyceride and LDL-cholesterol were lower in the UPSM_H group than those in the UPS group. suppressed fat accumulation in liver tissue. In the soybean group, the effects of inhibiting lipid deposition within liver tissue by hematoxylin and eosin (H&E) staining and fat accumulation suppression in fat cells by oil red-O staining were observed. Our results indicate that dose-dependent research can be used in a wide range of disease models such as liver disease improvement and metabolic syndrome, and the high concentration of soybean fermented with Monascus extract is much better.
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