Abstract

Soy pulp, a food by-product derived from tofu and soy milk production, is rich in insoluble dietary fiber, β-conglycinin, and isoflavones. The researchers developed hangover pills incorporating soy pulp. This study aims to investigate the effects of soy pulp extract-based hangover pills on antioxidant and alcohol-degrading activity through in vitro and human tests, including DPPH and ABTS radical scavenging activity, as well as breath alcohol concentration. Eighteen healthy volunteers participated in this randomized crossover study. The participants were randomly assigned to either the soy pulp mixture (SPM) intake group or the non-intake (PLA) group. The difference in blood alcohol concentration between the test and control groups was measured as the primary outcome. The breath alcohol concentration in the SPM group was significantly reduced by 35% after 15 minutes and 36% after 30 minutes compared to the PLA group post-alcohol consumption. DPPH and ABTS radical scavenging activity of SPM increased in a dose-dependent manner. SPM demonstrated higher antioxidant activity than both PLA and hangover pills from Company A. Therefore, hangover pills containing soy pulp, which exhibit antioxidant and anti-hangover effects, are anticipated to play a role in alleviating hangovers, aligning with the health and convenience needs of modern individuals.

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