Abstract
*Department of Medical Biomaterials Engineering, Kangwon National University, Chuncheon 200-701, Korea.**Department of Food Science and Engineering, Seowon University, Cheongju 361-742, Korea.ABSTRACT : This study was to investigate anti-skin wrinkle effect of Agastache rugosa Kentz extracts by extraction processes.In the comparison of the effect of the solvent extraction, the extracts by 70% ethanol (EE) showed better biological activitiesthat those by hot water. Therefore, further fermented Agastache rugosa was applied to 70% ethanol extraction process(FEE). FEE showed higher DPPH scavenging activity of 62.98% than EE’s 62.71% at 1.0 ㎎/㎖, but there was no significant.Elastase inhibition was measured 23.0% from FEE at 1.0㎎/㎖. Cytotoxicity showed the highest 16.26% from FEE, thisvalue is safe in the cell experiment. Collagen production showed 113.1 ng/ ㎖ from FEE, on the other hand EE was measured77.4 ng/㎖ in adding 1.0㎎/㎖. MMP-1 production was observed 1398 pg/㎖ from FEE and EE was measured1632 pg/㎖. These results were found the highest antioxidant and anti-wrinkle effect. As a result, it was also confirmed thatanti-skin wrinkle activities of the Agastache rugosa Kentz extract was correlated with anti-oxidant activities.Key Words : Anti-Skin Wrinkle Effect , Antioxidant, Agastache rugosa Kuntz, Collagen, Lactic Acid, MMP-1
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