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Abstract
Was studied the relationship between the parameters of carbohydrate and lipid metabolism, body mass index, HOMA-IR index and leptin concentration in patients with diabetes mellitus type 2 diabetes mellitus with normal motor-evacuation function of the stomach and gastroparesis (groups 1 and 2), as well as a comparison group with functional dyspepsia (Group 3). In patients with a high leptin content of 52.34 ± 4.31 ng / ml, according to the results of gastric ultrasound, there were signs of diabetic gastroparesis, predominantly moderate and severe (64.3%). Analysis of factors affecting the concentration of leptin among the studied groups showed the relationship of this hormone with BMI, insulin resistance, HOMA-IR index, and lipid metabolism disorders. In patients with diabetes mellitus type 2 and a BMI above 30.0 kg / m2, there was a significant (p <0.05) gastric motility disorders and hyperleptinemia when compared with patients of the first group without gastroparesis, who showed a statistically insignificant (p> 0.05) increase in leptin. The results of this study indicate a high content of leptin in the blood serum of patients with diabetic gastroparesis associated with a slowdown in metabolism due to gastric motility disorders, carbohydrate and lipid metabolism disorders and is a reliable diagnostic marker of the development and progression of complications in patients with type 2 diabetes mellitus.
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