Abstract
The paper presents the results of studying the functional properties of DNA aptamers during long-term storage for 5 years. The study was performed on 25 male mongrel rats, which, after the introduction of the DNA aptamer of the thrombin inhibitor 31RE with different synthesis periods, were determined by activated partial thromboplastin time (APTT) and prothrombin time (PTV). APTT and PV were deter-mined at intervals, 10, 60, 120 minutes after administration of the drug. The shelf life of the aptamer DNA from the moment of synthesis was: 1 month, 2 years, 5 years. According to the results of the study, it was found that the estimated shelf life of DNA aptamers is at least two years with a slight de-crease in activity.
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