Оценка ассоциации параметров диастолической дисфункции с суточными дозировками L-тироксина у пациентов с коронарной патологией сердца и первичным манифестным гипотиреозом

Abstract

The purpose — to identify possible associations of daily dosages of L-thyroxine with morphofunctional parameters of the myocardium in patients with chronic heart failure (CHF) of ischemic etiology and primary manifest hypothyroidism (PMH). Material and methods. A single-stage cross-sectional study was conducted with the participation of 90 patients with CHF of functional class I–II with ischemic etiology and PMH and 150 patients with CHF of ischemic etiology without hypothyroidism. The assessment of basic clinical parameters, morphofunctional parameters of the myocardium and their possible associations with daily dosages of L-thyroxine was carried out. Results. Statistically significant differences were found in the values of the ratio of the rate of early diastolic filling of the left ventricle and the average rate of elevation of the base of the left ventricle to the early diastole (E/e`), the left ventricular ejection fraction (LVEF) and the cerebral natriuretic peptide (BNP). Significant moderate correlations of the dosage of L-thyroxine (100 mcg/day) with the values of the ratio of the rates of filling of the left ventricle in the early diastole and in the atrial systole (E/A), E/e` and LVEF. Conclusion. L-thyroxine in high daily dosages can contribute to improving the values of morphofunctional parameters of the myocardium.