Асоціація звичного невиношування вагітності з алельними варіантами генів IL8 та IL10

Anastasiia Kucherenko,Ludmila Livshits,Roman Gulkovskyi,Iryna Vorobiova,Tamara Nakvasiuk,Kseniya Hazhylenko

doi:10.15587/2313-8416.2014.27254

Abstract

The study evaluated IL8 -781C/T and IL10 -592C/A, -1082A/G polymorphisms association with recurrent pregnancy loss (RPL) (n=110 case, n=106 control).IL10 -592АА genotype and -1082A allele carriers frequency was higher in RPL group (6.6 %, 87.3 %) comparing to control (0.9 %, 76.4 %). The -1082A allele carriers have twice increased RPL risk (OR=2.12; CI95 %: 1,03–4,34).

Highlights

The loss of three or more sequential pregnancies in the first trimester of gestation is defined as recurrent pregnancy loss (RPL)
Numerous studies were concentrated on the impact of allelic variants in cytokine genes on their expression and, as a result, the association of some polymorphisms with pathologies [5,6,7]
As to IL10 gene polymorphic variants, frequency of individuals with 592АА genotype was significantly higher in RPL group (6,6 %) comparing to control group (0,9 %)

Summary

Біологічні науки

RECURRENT PREGNANCY LOSS ASSOCIATION WITH ALLELIC VARIANTS OF IL8 AND IL10 GENES. © A. RECURRENT PREGNANCY LOSS ASSOCIATION WITH ALLELIC VARIANTS OF IL8 AND IL10 GENES. The study evaluated IL8 -781C/T and IL10 -592C/A, -1082A/G polymorphisms association with recurrent pregnancy loss (RPL) (n=110 case, n=106 control). IL10 -592АА genotype and -1082A allele carriers frequency was higher in RPL group (6.6 %, 87.3 %) comparing to control (0.9 %, 76.4 %). The -1082A allele carriers have twice increased RPL risk (OR=2.12; CI95 %: 1,03–4,34). Частота носіїв генотипа -592АА і алелю - 1082A гена IL10 була вище в групі НВ (6,6 %, 87,3 %) порівняно з контрольною (0,9 %, 76,4 %). Ризик невиношування у носіїв алелю -1082A вдвічі вище (OR = 2,12; CI95 %: 1,03-4,34). Ключові слова: IL8 ген / IL10 ген / інтерлейкін / звичне невиношування вагітності

Introduction

Findings

Conclusions