Эпидемиологическое значение хронической инфекции легких, вызванной бактериями рода Achromobacter, у пациентов с муковисцидозом

Abstract

Achromobacter is a genus of nonfermenting gram-negative bacteria that have particular clinical importance for patients with cystic fibrosis. Objective. To analyze epidemiological role of chronic lung infection caused by Achromobacter in patients with cystic fibrosis in Russia. Patients and methods. We examined 142 Achromobacter spp. isolates from sputum samples and throat swabs collected from 89 children and 53 adults. We used bacteriological and molecular methods (PCR, WGS) for identification and typing. Results. Our results demonstrated that newly identified chronic lung infection caused by Achromobacter spp. can be both nosocomial and community-acquired. Pathogens with different genotypes (ST36, ST261, ST184) are transmissive. Types ST36 and ST261 are found in several continents. Since 33.3% of patients infected with Achromobacter spp. were also found to have A. ruhlandii ST36, it can be defined as an epidemic clone. Our findings suggest high clinical and epidemiological importance of Achromobacter spp. Key words: Achromobacter spp., cystic fibrosis, a chronic lung infection