Abstract
Relevance. Life expectancy of cystic fibrosis patients mostly depends on the degree of respiratory system damage caused by opportunistic microorganisms, which is due to the fact that 90-95% of deaths of cystic fibrosis patients are caused by lung infections. Goal. To define epidemiologic characteristics of chronic lung infection caused by the most common agents (S. aureus, P. aeruginosa, B. cepacia-like bacteria (Bcc) and Achromobacter spp.) using a novel chronic lung infection in cystic fibrosis patients microbiological diagnosis algorithm. Materials and methods. Over a period of 7 years (2008-2016) 300 children with cystic fibrosis living in Moscow, Moscow region and several other regions of Russian Federation have been checked-up. 260 sputum samples from 100 adult patients, who were under care at the Pulmonology Research Institute, were studied. Sputum samples from children were taken before and after antibiotic therapy with intervals of 15-45 days and over 6 months. 30 of the children were also subjected to a microbiologic monitoring of the state of chronic infection in the period between 4 and 15 months. Sputum sample from adult patients were also taken before and after antibiotic therapy with intervals of 0, 15-45 days and over 6 months. Results. P. aeruginosa, S. aureus, H. influenzae and Burkholderia cepacia-like bacteria were confirmed to be the most common agents of lung infection in cystic fibrosis patients. Children with cystic fibrosis over the years develop foci of chronic lung infection, mainly caused by P. aeruginosa and S. aureus. Conclusions. Chronic lung infection can be caused by community-acquired or nosocomial S. aureus и P. aeruginosa. Chronic lung infection is a complex, dynamically changing disease which requires constant monitoring and is mainly caused by S. aureus, P. aeruginosa, Bcc bacteria and Achromobacter spp. As populations of the agents can be diverse, it is necessary to study all colonies with differing phenotypes (mucoid and non-mucoid variants, small colony variants, variants with different pigments) and to take samples of several colonies when testing antibiotic resistance. Bcc and Achromobacter spp. cannot be eradicated with antibiotics, thus the only effective measure against these bacteria can only be vaccination which requires developing a vaccine.
Highlights
Введение Муковисцидоз, или кистозный фиброз является наследственным аутосомно-рецессивным заболеванием, частота распространенности которого в России составляет 1:10 000 новорожденных [1]
As populations of the agents can be diverse, it is necessary to study all colonies with differing phenotypes and to take samples of several colonies when testing antibiotic resistance
Р. Основные механизмы изменчивости возбудителей хронической инфекции легких у больных муковисцидозом
Summary
Эпидемиологические особенности хронической инфекции легких у больных муковисцидозом. Резюме Цель исследования – представить данные о эпидемиологических особенностях вызванной разными видами бактерий хронической инфекции легких у больных муковисцидозом. Установлено, что при хронической инфекции легких, вызванной S. aureus и P. aeruginosa, возбудителей можно успешно эрадицировать с помощью антимикробной терапии, что невозможно в случае, когда возбудители инфекции бактерии комплекса B. cepacia и Achromobacter spp. Хроническая инфекция легких, вызванная бактериями видов S. aureus и P. aeruginosa, характеризуется многообразием генотипов, как внебольничным, так и внутрибольничным приобретением возбудителя инфекции. В то же время хроническая инфекция, вызванная бактериями комплекса B. cepacia и Achromobacter spp., является типичной госпитальной инфекцией, и больные муковисцидозом заражаются в больничных стационарах при передаче возбудителя от больного к больному. Хроническая инфекция легких у больных муковисцидозом сложное динамическое заболевание, требующее постоянного мониторинга в связи с возможными различными механизмами изменчивости возбудителя для проведения адекватного лечения больных и инфекционного контроля в больничных стационарах. Ключевые слова: хронической инфекции легких, муковисцидоз, мониторинг, внебольничные и внутрибольничные возбудители инфекции
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