Abstract
Lethal outcomes were studied in 704 tuberculosis patients in Kemerovo Region over 2 periods of time: 1995-1997 – 255 cases (including 229 with autopsy) and 2012-2014 – 449 cases (including 413 with autopsy) in three in-patient units of Kemerovo Regional Clinical TB Dispensary (continuous sampling). The number of those died during the second period increased due to co-infection of HIV and tuberculosis. During the second period there was an abrupt increase in disseminated forms of tuberculosis while the number of fibrous-cavernous forms went down, which was due to specific features of tuberculosis in HIV patients given the severe immune deficiency in them. At the same time the increase in the disseminated forms of tuberculosis was detected during the 2nd period in the HIV negative patients.
Highlights
Lethal outcomes were studied in 704 tuberculosis patients in Kemerovo Region over 2 periods of time: 1995-1997 - 255 cases and 2012-2014 - 449 cases in three in-patient units of Kemerovo Regional Clinical TB Dispensary
The number of those died during the second period increased due to co-infection of HIV and tuberculosis
During the second period there was an abrupt increase in disseminated forms of tuberculosis while the number of fibrous-cavernous forms went down, which was due to specific features of tuberculosis in H IV patients given the severe immune deficiency in them
Summary
Lethal outcomes were studied in 704 tuberculosis patients in Kemerovo Region over 2 periods of time: 1995-1997 - 255 cases (including 229 w ith autopsy) and 2012-2014 - 449 cases (including 413 w ith autopsy) in three in-patient units of Kemerovo Regional Clinical TB Dispensary (continuous sampling). - I группа и 413 - II группа) больные распределились следующим образом: умершие от туберкулеза - 210 (91,7%) больных I группы и 232 (56,2%) - II, ВИ Ч-инфекции, сочетанной с туберкулезом, - 166 (40,2%) больных II группы, в I группе таких больных не было, нетуберкулезных заболеваний, кроме ВИ Ч-инф екции, - 16 (6,7%) больных I группы и 15 (3,6%) больных II. Изучен состав вскрытых умерших от туберкулеза и сочетанной инфекции ВИЧ-инфекция/туберкулез (В И Ч -и /Т Б ) - 213 в I группе и 398 во II груп пе по клиническим формам туберкулеза
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