Динамика гематологических и биохимических показателей при респираторном синдроме ягнят

Abstract

Listen

Translate article

Respiratory Diseases 2010–2020 were the cause of death of 4,8–12,6 % of lambs. A trend towards an increase in the proportion of factorial infectious diseases was established, the epizootic index – 1,0, the breadth of distribution – 10,53. The mass fraction of respiratory diseases in lambs – 11,7–19,94 %. To reveal the pathogenetic mechanisms of the infectious process, prevent animal diseases and obtain safe livestock products, it is a priority to study the dynamics of hematological and biochemical parameters using standardized multilevel diagnostic algorithms. The development of the pathological process was characterized by a complex respiratory syndrome and was accompanied by cough, shortness of breath, nasal discharge, rhinitis, pharyngitis, tonsillitis, laryngitis, epiglottitis, laryngeal edema, tracheitis, bronchitis, hyperemia and pulmonary edema, bronchopneumonia, pulmonary emphysema, pleurisy, hydrothorax, pneumothorax . The dynamics of hematological parameters was characterized by an increase in the total number of leukocytes, neutrophils, eosinophils, basophils, lymphocytes and monocytes. Biochemical parameters were characterized by a decrease in total protein and glucose. An increase in urea and alkaline phosphatase was observed. A violation of the water and electrolyte balance was established: a decrease in the content of potassium, sodium and magnesium. An increase in the concentration of C-reactive protein was established – 9,34±2,80–11,54±1,08; decrease in the concentration of immunoglobulin IgA – 0,43±0,02–0,50±0.04 mg/ml; IgG – 7,60±0,19–12,40±2,10 mg/ml. The development of pathological processes is due to a decrease in immune reactions that prevent the adhesion of pathogens to the surface of epithelial cells. Mean adhesion score, SPA≥4,0 isolates: E. coli: O33:F41, O2:A20; K. pneumoniae; P. vulgaris; P. aeruginosa; S. aureus; C. albicans. Microscopic examination of swab preparations from the nasal cavity of sick lambs revealed predominantly coccal forms of microorganisms, as well as a large amount of mucus, erythrocytes, leukocytes, ciliated epithelial cells.