Abstract
It was tested and integrated the methodological approach to the research of xenobiotic compounds impact on protein molecules. For this purpose three groups of research methods were used: turbidimetry, immunochemistry and study of the impact on isoelectric point of proteins. The immunochemical methods are most specific. The turbidimetric methods are fastest and informative. Actually, the proposed methodological approach is integrated and versatile. These methods are effective for studying the xenobiotic influence on proteins in living organisms on the assumption of its complex applications. It was proved that this methodological approach is adequate, informative and easy to use.
Highlights
Предложен комплексный методический подход в исследовании влияния ксенобиотических веществ на молекулы белков
METHODOLOGICAL APPROACH TO THE EVALUATION OF XENOBIOTIC ENFFLUECE ON PROTEIN MOLECULES. It was tested and integrated the methodological approach to the research of xenobiotic compounds impact on protein molecules
The proposed methodological approach is integrated and versatile. These methods are effective for studying the xenobiotic influence on proteins in living organisms on the assumption of its complex applications
Summary
Запропоновано комплексний методичний підхід у дослідженнях впливу ксенобіотичних речовин на молекули білків. Із цією метою застосовували три групи методів дослідження: турбідиметричні, імунохімічні та вивчення впливу на ізоелектричну точку білків. Турбідиметричні методи найбільш швидкі у часі та інформативні. Слід підкреслити комплексність і універсальність запропонованих методичних підходів. Зазначені методи досліджень ефективні для вивчення впливу ксенобіотиків на білки живих організмів за умови їх комплексного застосування.
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