Abstract
Bladder cancer is characterized by a high mortality rate and is the 9th most common cancerous disease in the world. With a wide array of diagnostic bases, which include cystoscopy, ultrasound, computer and magnetic resonance imaging, cytology of urine deposition, it is difficult to accurately determine the extent of development of the tumor. It is important to find molecular and biochemical predictive parameters that would be characterized by high specificity and sensitivity to the tumor development. According to modern scientific data, an imbalance in the coagulation system is observed in cancer patients, the manifestation of which is the activation of the blood clotting system. Activation of the hemostatic system is accompanied by the appearance in the bloodstream of specific markers that reflect increase the hemostatic potential of the blood, such as the level of fibrin, fibrinogen, prothrombin time, activated partial thromboplastin time, activated plasma recalcification time. The results of a study of various cancers indicate an increased level of components of the plasminogen activation system, including the inhibitor of plasminogen activator-1 (PAI-1). The literature data that would indicate the prognostic significance of changes in the parameters of the blood clotting system and the proteolytic system in the blood in bladder cancer are few and have not completed. There are no data indicating the link between the studied parameters with histopathological gradation. In a detailed review of markers, it is possible to identify the optimal combination of markers of pathological processes, including the pathogenesis of oncological processes at various stages. During the study, we have investigated a significant increase in the level of fibrin, fibrinogen, and PAI-1, depending on the degree of bladder cancer. The test scores can make a significant contribution to the characterization of bladder cancer, depending on the grade according to the histopathological classification.
Highlights
The state of the glutathione-dependent link of the antioxidant blood system of rats under obesity development and with the compatible consumption of the kidney bean (P. vulgaris) pods extract was studied
The findings after 6-th weeks of kidney bean (P. vulgaris) pods extract consumption indicate the positive modulating effect of this extract on the content of GSH and the activity of glutathione peroxidase activity (GP), glutathione transferase (GT) and glutathione reductase (GR) in rats with the obesity development. The consumption of this extract leads to attraction of the investigated components of the antioxidant system to the reactions of neutralization of toxic free radical compounds that were formed against the background of the development of obesity
Further studies may serve as the basis for the development of new therapeutic or medicinal preparations that based on the kidney bean (P. vulgaris) pods extract, because of still no consensus on the treatment of obesity
Summary
The state of the glutathione-dependent link of the antioxidant blood system of rats under obesity development and with the compatible consumption of the kidney bean (P. vulgaris) pods extract was studied. Активація системи гемостазу супроводжується появою в кровотоці специфічних маркерів, які відображають ступінь підвищення гемостатичного потенціалу крові, таких як рівень фібрину, фібриногену, протромбінового індексу, активованого часткового тромбопластинового часу (АЧТЧ), активованого часу рекальцифікації (АЧР). Результати досліджень різних онкологічних захворювань вказують на підвищений рівень компонентів системи активації плазміногену, у тому числі на інгібітор активатора плазміногену-1 (PAI-1). У ході дослідження було виявлено значне порушення балансу деяких компонентів системи гемостазу в крові пацієнтів, а також рівень PAI-1 у пацієнтів, у котрих діагностовано РСМ різних стадій відповідно до гістопатологічної класифікації.
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Schedule a callMore From: Bulletin of Taras Shevchenko National University of Kyiv. Series: Biology
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