Abstract
Th e condition of collagen fi bres in the skin directly aff ects its mechanical properties, which in turn aff ects the external condition of the skin, refl ecting the age of a person. Th at is why the genetic aspects of the synthesis, functioning and degradation of collagen fi bres are of great interest in cosmetology and dermatology. Quite a large number of patients turn to cosmetologists in order to correct the external manifestations of aging. Classically, procedures are carried out to correct collagen synthesis, but development of personalised pathogenetically based therapy of involutional skin changes requires understanding of features of the main links of exchange in collagen fi bres, including the processes of collagen degradation. Knowing clinical and genetic features of collagen metabolism in a particular subject, it is possible to assess the risk of premature skin ageing and develop a personalised patient management scheme. Th is review is devoted to genetic aspects of functioning of skin collagen fi bres and the features of their degradation.
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