Глобальні інтеграційні та комунікаційні засади боротьби з антибіотикорезистентністю мікроорганізмів

Abstract

In the production of livestock products with therapeutic and prophylactic purpose, use antimicrobial drugs. Over time, pathogenic microorganisms develop mechanisms for adaptation to the negative effects of antibiotics. This phenomenon is called the acquisition of antibiotic resistance by a microorganism. At the global level, the question arises about the addiction of pathogenic microorganisms to certain types of antibiotics. The mechanism of addiction of pathogenic microorganisms to the use of antibiotics gave a significant impetus to pharmacologists to obtain our antimicrobial drugs. Aim: to investigate the current world experience in the study of the spread of antibiotic resistance pathogenic microorganisms and the main integration and the communication principles of combating this phenomenon. Results. The paper discusses the analysis of monitoring results under the auspices of the OIE for the dissemination of antibiotic-resistivity of microorganisms in 2013-1016. A parallel between the emergence of new antibiotics on the world veterinary market and the acquisition of the resistance of pathogenic microorganisms to new antimicrobial dosage forms have been made. The main causes of distribution and principles of struggle against antibiotic resistance of pathogenic microorganisms are highlighted. Attention is drawn to the fact that the increase of the industrial production of livestock products in Ukraine, the increase in the intensity of international trade in agricultural products, the large number of internally displaced persons, the migration of people, birds, and terrestrial wildlife contribute to the intensification of the issue of combating the spread of antibiotic resistant pathogenic microorganisms. It is suggested that the global problem of antibiotic resistance of pathogenic microorganisms at the present stage is controlled only in two ways, namely, legislative regulation of the circulation and use of antibiotics and the collection of information on the use of antimicrobial drugs in various fields of human activity. Regarding the monitoring of the presence and migration of antibiotic resistant strains of microorganisms, this issue is dealt with in varying degrees only in developed countries. This necessitates the adoption of a national program for controlling the circulation of antibiotics and the spread of antibiotic-resistant pathogenic microorganisms. The development of a national program to combat the spread of antibiotic resistant strains of microorganisms in Ukraine should be based on the principles of WHO and OIE, but the deduction of the peculiarities of our domestic legislation, livestock production, pharmacological and laboratory facilities is of key importance.