Вплив препарату Максідін на загальну резистентність організму собак розплідникового утримування

Abstract

In the conditions of dense keeping dogs are constantly faced with the attack of the representatives of conventional and conventionally pathogenic microflora, which ultimately leads to a decrease in resistance of animals. Thus, in the case of appearance of new animals in a kennel, or after visiting exhibitions and competitions it’s appropriate to use harmless and effective drugs to increase natural resistance of the organism. The aim of this work was to assess the effectiveness of Maxidin 0.4 in improving the natural resistance of dogs kept in the kennel. The work was carried out on 20 dogs which were divided into 2 equal groups. Dogs in the control group received saline at a dose of 1 ml. Dogs of the experimental group were inoculated with Maxidin 0.4 at a dose of 1 ml, subcutaneously. Clinically at the start of the study we noted the reduction of appetite, slight serous-catarrhal discharge from conjunctiva of eye and nasal cavity, ruffled hair. 5 days after application of Maxidin 0.4 dogs of the experimental group showed improvement of appetite, weakening or absence of the serous and serous-catarrhal discharge from the conjunctiva and nasal cavity, skin turgor increased, the animals become more active. At the start of the study blood analysis showed signs of anemia, erythropenia, slight leukopenia and increase in hematocrit. 5 days after administration of Maxidin 0.4 we observed disappearance of anemia, erythropenia and leukopenia, normalization of hematocrit. Serum levels of IFN-α and IFN-γ increased 3–6 times.Thus, Maxidin 0.4, which contains germanium in an easily digestible form improves the clinical state and normalizes blood counts in dogs kept in the kennel. Also Maxidin 0.4 was shown to increase the levels of IFN-α and IFN-γ in the blood serum of dogs, which is very important as in previous studies this effect was found only in experiments with laboratory animals.