Изучение эффективности применения пептидных препаратов при острых тяжёлых отравлениях этанолом

Abstract

Severe poisoning plays a significant role in ethanol poisoning and is an important cause of increased mortality in the population. Existing treatment regimens for extremely severe ethanol poisoning have shown low effectiveness, necessitating the search for drugs among pharmacological groups that have not previously been used in severe cases of ethanol poisoning. Peptides, which have demonstrated high efficacy in treating critical conditions of the body accompanied by impaired central nervous system and liver function, can be the drugs of choice. The aim of this study was to investigate the effectiveness of peptide drugs with neuroprotective and hepatoprotective activities in rats with acute severe ethanol poisoning. The studies were conducted on male albino rats, in which 40% ethanol was administered intragastrically using a probe at a dose of 1.5 LD50. The investigated pharmacological correction agents included the peptide drug Semax and a hepatoprotective agent with a peptide component, Molixan. The survival rate, average lifespan, neurological status, and vital functions (respiratory rate, heart rate, and body temperature) of the animals were evaluated. The results showed that administration of Semax and Molixan peptides increased the survival rate of rats and had a favorable effect on neurological status and vital body functions in cases of acute severe ethanol intoxication at a dose of 1.5 LD50. This study demonstrated the potential of using peptide drugs in cases of acute severe ethanol intoxication.