Abstract
Objective. To analyze age-specific etiology and clinical manifestations of enteroviral infections (EVIs) in children residing in Krasnodar region. Patients and methods. This retrospective study included 3,213 patients with confirmed EVIs registered between 2006 and 2018 and admitted to the Specialized Clinical Children's Hospital for Infectious Diseases. Polymerase chain reaction was used to confirm the diagnosis. Results. We found that the most common enteroviruses circulating in Krasnodar region for many years were Coxsackie B virus and ECHO viruses 6, 11, and 30. The majority of patients (75.1%) had isolated forms of infection. Almost one-third of children (27.8%) demonstrated central nervous system lesions (primarily meningitis) that were more common in children aged 3 to 12 years. Other clinical forms were observed in young children. Almost all children hospitalized (91%) attended kindergartens. Conclusion. Coxsackie B virus and ECHO viruses 6, 11, and 30 have been circulating in Krasnodar region for the last 12 years; enterovirus type 71 has recently been found in this area. The highest proportion of EVI cases requiring inpatient treatment was observed among young children, in whom EVIs primarily manifested with meningitis. Primary school children usually had herpangina and exanthema, while older children developed epidemic myalgia. Our findings indicate the need for a set of measures aimed at reducing the incidence of EVIs among children of Krasnodar region. Key words: children, enteroviral infection, Krasnodar region, epidemiology, clinical manifestations, diagnosis
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