Плацентарна дисфункція у вагітних із супутньою патологією серцево-судинної системи

Abstract

The objective: study of the effect of Tivomax on the parameters of utero-placental-fetal blood circulation in patients with placental dysfunction and concomitant extragenital pathology of the vascular system. Patients and methods. The study included 60 pregnant women diagnosed with the diagnosis «placental dysfunction», after 22 weeks of gestation and concomitant extragenital pathology of the vascular system, including varicose veins, thrombophlebitis and endarteritis. All patients were randomly divided into the main (30 patients) and control (30 patients) epidemically equivalent groups. During the survey, clinical, laboratory and instrumental (ultrasound) methods of examination were used. Observation of patients was carried out both during pregnancy and in the postpartum period. Results. The study of the efficacy of Tivomax, 4.2% solution for infusions, against the background of the generally accepted regimen for the treatment of placental dysfunction showed that under the influence of the proposed therapy, dopplerogram normalization occurs by decreasing peripheral resistance in the microvascular bed of the placenta, increasing placental perfusion, and optimizing blood flow in the vessels. The conclusion. The purpose of the drug Tivomax contributes to the normalization of the dopplerogram by reducing the peripheral resistance in the microvascular bed. The drug Tivomax has no adverse reactions, negative changes in laboratory blood counts. Timely correction of management of pregnancy and childbirth, drug therapy, conducted in accordance with dopplerometric indicators, can reduce perinatal morbidity and mortality. Key words: Tivomax, L-arginine, endothelium, obstetrics and gynecology, placental disfunction, cardiovascular pathology, extragenital pathology.