Изучение окислительных процессов при развитии сахарного диабета у экспериментальных животных

Abstract

The gradual destruction of β-cells of the pancreas leads to insulin deficiency, diabetes mellitus develops, which is manifested by severe disorders of carbohydrate-energy metabolism, chronic hyperglycemia is accompanied by an imbalance of all functional systems of the body. Therefore, it is possible to study metabolic processes that can lead to the gradual destruction of β-cells. The aim of this study was to investigate the processes of lipid peroxidation in the total homogenate of the pancreas and liver of alloxaninduced rats, the amount of nitric oxide, and the state of the thiolisulfide system. As it is stated by the results of the study, the oxidative processes in the total homogenates of the pancreas and liver of model rats showed accumulation of lipid peroxidation products (hydroxides, malondialdehyde, Schiff bases). In alloxan-induced diabetes mellitus, a decrease in the SH content, an increase in the content of oxidized SS-groups of thiols and NO were found in the pancreas. According to the results of our research, it can be concluded that with the development of alloxan diabetes, an increase in the concentration of active compounds in the pancreas and liver is observed, which leads to disruption of the normal functioning of metabolic processes.