Abstract
Tuberculosis refers to one of the socially significant diseases. The scientific literature justifies the feasibility of using polymer matrices to immobilize protuberculous drugs, which contributes to the completion of phagocytosis. Comparative study of antituberculosis activity of analogues of isonicotinic acid hydrazide condensate in treatment of experimental tuberculosis in mice was carried out. The effectiveness of using chlorohydroxychitosan complex with 1-isonicotinyl-2-D-glucosyl hydrosone with included Co2 + has been established in comparison with chitosan-cobalt-1-isonicotinyl-2-D-glucosyl hydrosone in treating experimental tuberculosis. Immunostimulatory activity of polymer metal complex comparable to chitosancobalt-1-isonicotinyl-2-D-glucosyl hydrosone complex was revealed. The results obtained in the experiment can be used in the development of modern, treatment methods for tuberculosis.
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