Abstract
The prevalence of gastroesophageal reflux disease is steadily rising. The number of patients with non-erosive reflux disease is increasing worldwide, including the form of the disease refractory to standard therapy. This article presents current data on the pathogenesis, diagnosis, and therapeutic approaches for patients with refractory non-erosive reflux disease. Key words: proton pump inhibitors, non-erosive reflux disease, refractory symptoms
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