Abstract
Spine sarcoma is one of the cancers with the most negative prognosis due to its tendency to rapidly metastatic spread. It is believed that the rapid growth of the tumor and its metastatic spread are associated with favorable mechanical properties of bone tissue for the development of the tumor process. The paper presents a macromodel of the thoracic segment T4-T5 with a tumor under shock wave exposure through an applicator located on the lamina. Simulation data were analyzed based on the principles of mechanodestruction of cancer cells and stroma. The results show that low- and moderate-intensity shock wave impact can promote the deactivation of cancer cells in a large tumor volume. High-intensity shock wave loading can promote the deactivation of cancer cells. However, it also promotes the formation of stroma around the tumor and the risk of destruction of bone tissue near the applicator. The data obtained show the need for further study of the factors influencing the neoplastic process in order to minimize tumor growth and prevent the spread of metastases at the initial stage of the disease.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call