Abstract
A common complication of HBV and HCV is liver cirrhosis, which is based on chronic systemic inflammation associated with immune dysfunction that affects the progression of the disease. The purpose of the study. Determination of NLR and lymphocyte apoptosis index as a marker of the degree of inflammation and systemic immuno-inflammatory response in various degrees of liver fibrosis in patients with viral hepatitis. Materials and methods. 107 patients underwent the study, of which 53 patients were diagnosed with HBV and 54 with HCV. The blood levels of leukocytes, neutrophils, and lymphocytes were studied in the studied patients and the neutrophil/lymphocyte ratio (NEU/LYM) was determined. In order to verify structural changes in the liver, ultrasound elastometric examination was performed on a 2D – Supersonic Aixplorer SWE device (France) for all persons with esTableished viral hepatitis. The examination of patients was carried out according to the Cut–off scale, and liver fibrosis was determined by the METAVIR scale. A group of 10 practically healthy individuals was selected as a comparison group. The values of the indicators were expressed in kPa, the value of the indicator 7.1 kPa corresponded to F2, 9.2 kPa – F3, F4≥13.5 kPa. Verification of HBV and HCV was carried out by PCR on the device “Rotor Qene Q” (Germany). The results obtained showed an increase in the absolute number of lymphocytes with a decrease in the NLR indicator against the background of a decrease in the apoptosis marker of CB95+ lymphocytes with varying degrees of liver fibrosis. A decrease in this marker reflects the damaging effect of hepatotropic viruses, which is indirectly confirmed by the detected leukocytosis. Keywords: viral hepatitis, liver cirrhosis, systemic inflammation, neutrophil to lymphocyte ratio, prognostic marker.
Published Version
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