Селективный дефицит иммуноглобулина А в сочетании с селективным дефицитом иммуноглобулина G4 у взрослого пациента

Abstract

Aim. To demonstrate the possibility of developing primary immunodeficiency with impaired antibody synthesis in an adult patient and discuss the algorithm for laboratory diagnostics and treatment tacticsto demonstrate the possibility of developing primar hypoimmunoglobulinemia after a course of imunosupressive therapy. Key points. Primary immunodeficiencies are a group of diseases associated with monogenic mutations. They do not have a typical clinical picture. A clinical observation is presented, when a selective deficiency of immunoglobulin A in combination with a selective deficiency of the subclass of immunoglobulin G was detected in a patient with chronic bronchopulmonary pathology. Clinical and laboratory criteria for diagnosis and treatment tactics are discussed. Сonclusion. Primary immunodeficiencies are often hidden by infectious masks. It is necessary to study serum immunoglobulins, with their normal levels or selective deficiency of immunoglobulin A, to additionally investigate the content of subclasses of immunoglobulin G. Keywords: primary immunodeficiency, selective immunoglobulin A deficiency, immunoglobulin G subclass deficiency.