Abstract
Background. Malignant tumors management using conventional treatment modalities is associated with poor outcomes. Objective of the study. To assess photodynamic activity of Photolon as monotherapy, as well as in combination with radio- and chemotherapy in an experiment.Material and methods. The research was done on HeLa monolayer culture (human uterine cervix carcinoma), 97 white random-bred rats with Pliss lymphosarcoma and 42 mice (CBA) with uterine cervix cancer-5 (UCC-5). Results. The amplification factor in Photolon photoirradiation was 65.1 in terms of the cytostatic effect and 98.5 in terms of cytotoxic effect. Photodynamic therapy enhances the efficacy of radiotherapy, since it reduced Pliss lymphosarcoma growth rate in rats down to 33.7% and UCC-5 growth rate in mice down to 14.9% of the intact control level (p<0.05). Conclusion. It is advisable to include photodynamic therapy in multimodality treatment.
Highlights
Malignant tumors management using conventional treatment modalities is associated with poor outcomes
HeLa в экспозиционной дозе 5 Дж/см2 после инкубации с ФС в течение 3 часов приводит к статистически значимому уменьшению числа жизнеспособных клеток
Фотооблучение опухолевых клеток HeLa в экспозиционной дозе 5 Дж/см2 после инкубации с фотолоном в течение 3 часов приводит к развитию выраженных цитотоксического и цитостатического эффектов
Summary
Malignant tumors management using conventional treatment modalities is associated with poor outcomes. Фотодинамическая терапия повышает эффективность лучевой терапии, поскольку снизила индекс роста лимфосаркомы Плисса у крыс до 33,7% и РШМ-5 у мышей до 14,9% от уровня интактного контроля (p
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