Ранняя диагностика и профилактика кардиоваскулярного риска у больных сахарным диабетом 2 типа

Abstract

In the paper the relevance of research associated with a high incidence in the world diabetes type 2 diabetes, with often development in patients with early and late, micro - and macro-vascular complications leading to disability and mortality is justified. The results of study on the complex clinical and anamnestic, biochemical, metabolic, functional risk factors for cardiovascular diseases are presented. By means of multivariate mathematical modeling the most informative predictors of complications and their combinations, associated with increased susceptibility to the development of macro-angiopathies in the patients with diabetes mellitus type 2, were defined. The importance of lipid disorders, metabolic profile and homocysteine in the development of cardiovascular complications and their progression based on the study of the correlation between homocysteine with lipoproteins in various forms macro-angiopathies of patients with diabetes type 2, has been demonstrated. Timely correction of identified violations promotes positive dynamics of metabolic processes and on this background, to reduce the frequency of cardiovascular complications. The obtained data contribute to a better understanding of the mechanisms of formation, disposition, development, clinical course and outcome of diseases, identification of the population of persons with risk factors for the purpose of prevention activities.