Abstract
Redistribution of blood in the vascular system in the condition of gravitational unloading causes changes in venous blood flow inboth humans and laboratory animals; however, dependence of these changes on the alterationsin contractile activity of venous walls and mechanisms involved are not sufficientlyexplored. Purpose of the work is to design an experimental setupand procedure for studying the effects of microgravity on the venous vesselsin mouse, the most common object of animalspace experiments. The proposed procedure consists of recording the contractile activity of the longitudinal smooth layer of the portal vein wall, and itschanges due to actionof pharmacological agents. Frequency of venous contraction changes in response to different factors more significantly than the contraction amplitude and tone level. The resultswill serve as a basis for developing an optimal protocol of studying the mechanisms of changes in venous contractility in mice as part of space experiment BION-M2.
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