Abstract
Background. The study of new methods of treating frostbite is feasible using an experimental model, the effectiveness of which is confirmed by morphological results. Purpose of the study. Morphological substantiation of the effectiveness of the developed device for simulating contact frostbites of varying severity. Material and methods. In 30 laboratory rats, the designed device was used to simulate cold trauma of varying severity. The material for morphological research was collected at different time intervals. Results. Morphological argumentation of the effectiveness of the created device for reproducing both superficial and deep frostbites is presented. Conclusions. The developed device is not difficult to manufacture; it is safe and allows reproducing standardized contact frostbites of varying severity in laboratory animals.
Highlights
The study of new methods of treating frostbite is feasible using an experimental model, the effectiveness of which is confirmed by morphological results.Purpose of the study
Figure 9. – Frostbite zone (1) and histological section (2) on the 11th day after contact cold exposure
– Зона криоповреждения (1) и гистологический срез (2) на 27 сутки после холодового воздействия (рана эпидермизировалась (а), коллагеновые волокна в дерме располагаются упорядоченно (б), воспалительная инфильтрация отсутствует)
Summary
The study of new methods of treating frostbite is feasible using an experimental model, the effectiveness of which is confirmed by morphological results.Purpose of the study. Цель исследования – морфологическое обоснование эффективности разработанного устройства для моделирования контактных отморожений кожи разной степени тяжести. – Зона контактного отморожения (1) и гистологический срез (2) на третьи сутки после холодового воздействия (в дерме и подкожной клетчатке определяется венозное полнокровие (а) и отек (б).
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