Abstract
Objective of the Review: To demonstrate the role of changes in disaccharidase activity in aetiology and pathogenesis of functional enteropathies (FEP). Key Points. In mid-20th century, Russian scientists found out that jejunum diseases can be caused by impaired membrane digestion (MD). Not it is known that irritable bowel syndrome and other FEPs can mask enteropathies with impaired MD. Conclusion. Measurements of disaccharidase activity in duodenum mucosa are a method of choice in diagnosing enteropathies with impaired MD. The information on disaccharidase activity in ileum have not been described in any references. It is assumed that disaccharidase measurements in distal jejunum can be of extra diagnostic significance in examination of patients with FEP. Available information will make it possible to propose an up-to-date concept of aetiology, pathogenesis, clinical course, diagnosis and management of disaccharidase deficiency. Keywords: irritable bowel syndrome, disaccharidases, membrane digestion, A. M. Ugolev, Dahlquist method, FODMAP diet, Rebamipide, probiotics.
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