Abstract
Enalapril, belonging to the class of ACE inhibitors, is one of the leading drugs in the treatment of cardiovascular diseases and is used to treat essential hypertension of any severity, renovascular hypertension, heart failure and its prevention, as well as the prevention of coronary ischemia in patients with left ventricular dysfunction. Increasing requirements for the quality of pharmaceutical substances and pharmaceutical dosage forms create conditions for improving existing and creating new analytical developments performed using modern instrumentation. A promising method for quality control of pharmaceutical substances is the method of galvanostatic coulometry, in particular, coulometric titration with electrogenerated hydroxide ions, in which the main controlled parameters are time and current flowing through the electrochemical cell. Electrogenerated hydroxide ions are formed during the electrolysis of water. As an electron carrier, sodium sulfate, potassium sulfate, and other salts are usually used. Currently, devices are being produced that allow you to measure these parameters automatically with high accuracy. Galvanostatic coulometry is distinguished by the simplicity of the experiment, rapidity, and accuracy. Does not require expensive equipment, preliminary standardization of the titrant, the use of standard samples (except for the determination of water by the Karl Fischer method). Electrogenerated hydroxide ions interact with enalapril maleate quickly and quantitatively in a ratio of 3:1. Unified methods have been developed for the quantitative determination of enalapril maleate in the substance and tablets by coulometric titration with electrogenerated hydroxide ions. The auxiliary components of the tablet mass do not interfere with the determination of the active ingredient. The relative standard deviation does not exceed 0.6%, the relative error of the mean does not exceed 0.8%. Methods can be used in the practice of control and analytical laboratories to assess the parameter "Assay" in the substance and tablets.
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