СОСТОЯНИЕ ПОЧЕЧНОГО ФУНКЦИОНАЛЬНОГО РЕЗЕРВА У БЕЛЫХ КРЫС ПРИ ФИЗИОЛОГИЧЕСКОМ ТЕЧЕНИИ БЕРЕМЕННОСТИ

Abstract

THEAIM of the investigation was to study the state of renal functional reserve in rats during pregnancy. MATERIAL AND METHODS. The investigation was performed in 4 groups of white laboratory rats: groups 1 and 2 - non-pregnant rats with body mass 215-250 g, groups 3 and 4 - pregnant rats (second half of pregnancy, mass of the fetuses 3-5 g) with body mass 240-270 g. The value of renal functional reserve was determined by increased creatinine clearance between groups of animals under conditions of water loading (basal CFR values) and acute osmotic loading with 3% solution of sodium chloride (stimulated CFR values). The state of the tubular portion of the nephron was analyzed on the basis of investigating renal excretion of calcium, phosphates, osmotically active substances and protein. RESULTS. Itwas found that in rats with physiological course of pregnancy the value of renal functional reserve was increased which was followed by increased excretion of endogenous nitrates and nitrites. It was also shown that during physiological course of pregnancy the renal regulation of osmotic homeostasis was more exact. CONCLUSION. 1. The value of the renal functional reserve in rats increases during pregnancy. 2. Renal excretion of inorganic nitrogen oxides increases in rats during physiological development of pregnancy. 3. Renal mechanisms of regulation of osmotic homeostasis work more exactly in pregnant rats.