Эффективность локальной цитокинотерапии в комплексном лечении цервицита, ассоциированного с папилломавирусной инфекцией

Abstract

Objective. To study the efficacy of local cytokine therapy with Superlymph® 25 units in the complex treatment of chronic cervicitis (vaginitis) combined with other lower urinary tract infections and associated with human papillomavirus (HPV) infection. Patients and methods. We conducted a comprehensive examination of 123 women aged 18 to 35, who were divided into two clinical groups. The control group included 50 patients with clinical and laboratory parameters corresponding to the standard reference ranges. The study group included 73 patients diagnosed with HPV-associated cervicitis and lower urinary tract infections. The laboratory examination included a vaginal pH test using colposcopy (colpotest), bacterioscopic and bacteriological methods, and a real-time polymerase chain reaction method. HPV typing was performed using a “Quantum 21” test. Results. Local cytokine therapy in the complex treatment of chronic cervicitis in patients with lower urinary tract infections contributes to the statistically significant restoration of vaginal microbiocenosis, promotes the growth of Lactobacillus biotype (p < 0.001), reduces cervicitis and cystitis recurrence rates during the year (p < 0.001), accelerates HPV elimination and reduces viral load (p < 0.001). Conclusion. The use of local cytokine therapy with Superlymph® 25 units in the complex treatment of chronic cervicitis (vaginitis) in patients with lower urinary tract infections contributes to the restoration of vaginal microbiocenosis and reduction of cervicitis and cystitis recurrence rates during the year. Key words: human papillomavirus, cervicitis, lower urinary tract infections, cytokine therapy