Abstract
238 tuberculosis cases with concurrent HIV infection were examined. The age of patients varied from 24 to 57 years old. Men made 189 (79.4%), and women 49 (20.6%). The CD4 count in the examined patients varied from 0 to 1.216 × 10 9 /L. The intensity of systematic inflammatory response was evaluated as per the rates of acute phase reactants: С-reactive protein (СRP), α 1 -antitrypsin (α 1 -АТ), haptoglobin (HG) and fibrinogen (F). It was found out that tuberculosis patients with concurrent HIV infection demonstrated confidently increased levels of C-reactive protein, α 1 -antitrypsin, and haptoglobin, which was the evidence of systemic inflammatory response. However, the increase of fibrinogen level was not typical of tuberculosis patients with concurrent HIV infection. The comparative analysis proved that the intensity of systemic inflammatory response was increasing simultaneously with the severity of the immune deficiency, and the growth of acute phase reactants' level with a parallel reduction of CD4 count was the evidence of the above. C-reactive protein and α 1 -antitrypsin were the most informative markers of systemic inflammatory response intensity in tuberculosis patients with concurrent HIV infection.
Highlights
Обследовано 238 больных туберкулезом легких, сочетанным с ВИЧ-инфекцией
It was found out that tuberculosis patients with concurrent HIV infection demonstrated confidently increased levels of C-reactive protein, α1-antitrypsin, and haptoglobin, which was the evidence of systemic inflammatory response
The comparative analysis proved that the intensity of systemic inflammatory response was increasing simultaneously with the severity of the immune deficiency, and the growth of acute phase reactants' level with a parallel reduction of CD4 count was the evidence of the above
Summary
Возраст пациентов колебался от 24 до 57 лет. Распад в легочной ткани диагностировался у 38 (16,0%) пациентов. Количество СD4-лимфоцитов у обследованных больных колебалось от 0 до 1,216 × 109/л. При этом у 99 (41,6%) больных число СD4-лимфоцитов составило более 0,5 × 109/л, у 16 (6,7%) – 0,35-0,5 × 109/л, у 35 (14,7%) – 0,2-0,35 × 109/л, у 59 (24,8%) – 0,2-0,05 × 109/л и у 29 (12,2%) – менее 0,05 × 109/л. Исследовали сыворотку/плазму крови при поступлении больных в клинику. У всех пациентов было получено письменное добровольное информированное согласие на участие в исследовании. Проверку гипотезы о равенстве средневыборочных величин при их нормальном распределении проводили с использованием t-критерия Стьюдента. Различия считали статистически достоверными при значении p < 0,05. Оценку взаимосвязей изучаемых показателей осуществляли путем вычисления коэффициента корреляции Спирмена, величину которого считали статистически значимой при p < 0,05
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
