СРАВНИТЕЛЬНАЯ ОЦЕНКА ЭФФЕКТИВНОСТИ РАЗЛИЧНЫХ СХЕМ ТЕРАПИИ КАМПИЛОБАКТЕРИОЗА У ДЕТЕЙ РАННЕГО ВОЗРАСТА

Abstract

Campylobacteriosis is one of the most common bacterial intestinal infections with a high risk of severe course in childhood. The treatment of children with campylobacteriosis is complex and requires further study. Objective of the study: to study the clinical efficacy of various drug therapy regimens for campylobacteriosis and their effect on intestinal microbiocenosis in young children. Materials and methods of research: From 2018 to 2020 in the Pediatric Research and Clinical Center for Infectious Diseases of the Russian Federal Biomedical Agency, a comprehensive singlecenter prospective dynamic open observational study of 84 children aged 6 to 18 months with campylobacteriosis was carried out (41 boys, 43 girls, mean age 12,7±4,7 months). A comparison was made between patients who did not receive an antibacterial drug (n=30), received azithromycin (n=30), and received several antibacterial agents (n=24). Clinical and laboratory parameters and indices of the intestinal microbiocenosis composition were assessed by real-time PCR. Results: antibacterial drugs of the macrolide group are most effective in the etiotropic therapy of severe and moderate forms of campylobacteriosis in infants. The appointment of antibacterial drugs of the cephalosporin group for campylobacteriosis leads to a slowdown in the recovery process (an increase in the duration of diarrhea, fever and abdominal pain), accompanied by significant damage to the intestinal microbiocenosis (a decrease in the symbiotic Lactobacillus spp. and Bifidobacterium spp.). The combination of these factors predisposes to more frequent re-isolation of the pathogen observed in this group of patients. For children who are on mixed or artificial feeding, the inclusion of nutritional mixtures with probiotics in the complex of therapeutic measures has a pronounced therapeutic effect and can be used as one of the main means of rehabilitation of campylobacteriosis convalescents.