Abstract
ABSTRACT. A Kinetics pathway of oxidation of Cefpodoxime Proxetil by permanganate in alkaline mediu m at a constant ionic strength has been studied spectrophotometrically. The reaction showed first order kinetics i n permanganate ion concentration and an order less than unity in cefpodoxime acid and alkali concentrations. Increasing ionic strength of the medium increase the rate. The oxidation reaction proceeds via an alkali-permanganate species which forms a complex with cefpodoxime acid. The latter decomposes slowly, followed by a fast reaction between a free radical of cefpodoxime acid and another molecule of permanganate to give the products. Investigations of the reaction at different temperatures allowed the determination of activation parameters with respect to the slow step of proposed mechanism and fallows first order kinetics. Theproposed mechanism and the derived rate laws are consistent with the observed kinetics. Keywords: Cepfodoxime proxetil, Permanganate, Kinetics, Themodynamics
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