Abstract
As a result of widespread use of antibiotics, a large number of microbial strains have acquired resistance to drugs of this group. Benzoic acid is widely used in many industries: in the food industry as a preservative, in medicine and veterinary medicine as an antiseptic agent. Despite the effectiveness of benzoic acid as an antibacterial component, its use is limited by its low solubility in water. Currently, an actual direction in chemical technology is the direction of modifying the properties of biologically active substances by obtaining their multicomponent compositions with improved properties. One of the technological methods to increase solubility of poorly soluble biologically active substances is obtaining solid dispersions of these substances. There are no data on the introduction of benzoic acid into the composition of solid dispersions. This served as a prerequisite for the development of solid dispersions of benzoic acid with subsequent study of their properties. The aim of this work was to obtain and study the properties of solid dispersions of benzoic acid with polyvinylpyrrolidone K 12. The solubility of benzoic acid from solid dispersions based on polyvinylpyrrolidone K 12 was studied. The application of this technological technique increased the solubility of benzoic acid by 3.5 times. The studies carried out by means of X-ray phase analysis, IR spectroscopy and determination of particle sizes by dynamic light scattering method allow us to assume that an increase in the solubility of benzoic acid from its solid dispersions is caused by obtaining a system with its highly dispersed crystalline phase in polyvinylpyrrolidone K 12, solubilising effect of the latter and formation of colloidal solution of benzoic acid when its solid dispersion is dissolved.
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