Abstract
Aim: this study is aimed at investigation concerning the efficacy and tolerability of the terpene-containing dietary supplement Vitaterpen Active® in clinical practice for patients with chronic alcoholic hepatitis (CAH). Materials and Methods: a non-interventional open study was conducted involving 20 patients (both male and female, aged 20 to 75) suffering from CAH. The patients had altitudes (ALT) not exceeding the upper limit of normal by more than 3.0 times. In addition to basic therapy, all participants took Vitaterpen Active® orally, at a dosage of 3 capsules per day (75 mg/kg body weight) after meals for 1 month. Treatment efficacy was assessed using the changes of liver and spleen ultrasound data, biochemical serum markers (alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, alkaline phosphatase, γ-glutamyl transpeptidase (GGT), creatinine), complete blood count parameters, liver fibrosis index assessed through the Bonacini score with international normalized ratio, platelet count, ALT/AST ratio, and results from clinical examination focusing on the changes of symptoms like abdominal pain/heaviness, nausea/vomiting, belching/bloating, and changes in stool patterns. Results: the investigation into the efficacy of the terpene-containing supplement in patients with CAH and cholestasis syndrome revealed positive trend. After one month of treatment, efficacy was confirmed by a significant reduction in cytolysis markers (ALT, AST), cholestasis markers (GGT) in 90% of patients, liver fibrosis index in 45% of patients, reduction in clinical symptoms of CAH and complete symptom resolution by the end of the treatment course. The supplement was well-tolerated, with no adverse effects reported. Conclusion: the terpene-containing dietary supplement Vitaterpen Active® can be considered a promising hepatoprotective agent in the treatment of CAH with cholestasis syndrome. KEYWORDS: chronic alcoholic hepatitis, cholestasis, terpenes, hepatoprotective agent. FOR CITATION: Petukhova S.V., Zverkov I.V., Bibova O.A., Rashitova E.L. Promising natural hepatoprotector based on terpenes in the treatment of chronic alcoholic hepatitis. Russian Medical Inquiry. 2024;8(7):439–443 (in Russ.). DOI: 10.32364/2587-6821-2024-8-7-11.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call