Abstract
The analysis of lipid peroxidation (LPO) and antioxidant protection (concentration of α-tocopherol and superoxide dismutase) in the blood serum of patients with adenomyosis was performed. The levels of conjugated dienes (CD), malondialdehyde (MDA), superoxide dismutase (SOD), and α-tocopherol were significantly higher prior to treatment (organ-preserving endoscopy + drug therapy) than those in the control group (patients with tubal infertility). At the same time, SOD activity was almost 2-fold lower, and MDA levels were 2-fold higher compared to the normal values. After surgery, progestogens, magnesium supplements, and indole-3-carbinol+resveratrol (1 tablet once a day for 3 months) were prescribed to all patients. After combination therapy, all the parameters of free radicals and antioxidant protection changed significantly: they did not reach the control values but were close to them to such an extent that the difference between the levels of MDA, CD, SOD, and α-tocopherol in the blood serum of patients in the control group and that of patients with adenomyosis was found to be insignificant. Moreover, the percentage of variation (improvement) of CD and SOD exceeded 40%. Conclusion. Under certain conditions, intrauterine endoscopy in combination with postoperative drug therapy can provide longterm relief of pathognomonic symptoms of adenomyosis. Key words: adenomyosis, reproductive age, antioxidant system, indole-3-carbinol+resveratrol
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