Abstract

The article presents the mechanisms of action of the main external (polluted air, polluted water, dairy products, foods with a high glycemic index, pollutants, nicotine, alcohol, drugs, xenobiotics, etc.) and internal (cytokines, interleukins, eicosanoids, free radicals, oxidative stress, lipopolysaccharides, etc.) environmental factors in the development of acne vulgaris. Internal and external environmental factors play a significant role (estimated at about 10%) in the pathogenesis of acne vulgaris, the study of which makes it possible to develop more effective approaches of the prevention and treatment of this disease.

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