Изучение роли цинка в образовании хромосомных аберраций с помощью расчетного метода оценивания

Abstract

The composition of dust in industrial citi1s indicat1s the presence of these large concentrations of heavy metals indicates their ability to exert mutagentic, often manifested as chromosomal aberrations. The aim of the article was to study the role of zinc in the formation of chromosomal aberrations. The article shows the frequency of occurrence of chromosomal aberrations in a population, that lives in conditions of increased chemical pollution. The level of chromosomal aberrations in individuals living in the territory of an ecological disaster was studied. The types and nature of cytogenetic disorders are highlighted. The calculation of the individual dose loads of the intake of chemicals into the body from the environment. The simulation method presents the role of zinc in the formation of chromosomal aberrations. A significant inverse correlation was found between the frequency of chromosomal abnormalities and the zinc content in atmospheric air (the Pearson pair correlation coefficient was –0.39). It has been proven that with a decrease in the concentration of zinc in atmospheric air, the level of chromosomal aberrations increases statistically significantly. We described the co-enzymatic activity of zinc in the enzymes of the repair system and antioxidant defense. It was noted that chromosomal aberrations are sensitive to various exogenous and endogenous effects of environmental factors, which affect the functional changes of these cells. As a result, specific disturbances are determined.