Abstract
Purpose To assess osseointegration of implants made of various osteoconductive materials in an animal experiment by management of a long-bone diaphysis defect complicated with chronic osteomyelitis. Materials and methods Experimental studies were conducted on 24 healthy outbred adult rabbits for six weeks. Diaphyseal defects were managed with allo-, ceramic, and carbon implants. Results and discussion With carbon material, an adhesive interaction between the implant and the maternal bone tissue was of intercalation type. Osteointegration was evidenced by the presence of microfragments of an implant in bone tissue extracted for morphological study from the peri-implant zone, with areas of numerous osteoid islets. With a ceramic implant in the defect, no signs of remodeling and osteointegration in the implant extracted for morphological examination of bone tissue were detected. In the experiment with allograft, the area of implantation was isolated by a fibrous capsule, in which individual osteo-osteoid areas were seen without typical bone structure formation, and complete bone fusion was not achieved. Conclusion Morphological data on the regeneration processes prove the advantages of a carbon nanostructured implant relative to the other osteoplastic materials used in this animal experiment.
Highlights
To assess osseointegration of implants made of various osteoconductive materials in an animal experiment by management of a long-bone diaphysis defect complicated with chronic osteomyelitis
Osteointegration was evidenced by the presence of microfragments of an implant in bone tissue extracted for morphological study from the peri-implant zone, with areas of numerous osteoid islets
With a ceramic implant in the defect, no signs of remodeling and osteointegration in the implant extracted for morphological examination of bone tissue were detected
Summary
Morphological data on the regeneration processes prove the advantages of a carbon nanostructured implant relative to the other osteoplastic materials used in this animal experiment. В настоящее время для замещения дефектов костной ткани получило широкое распространение применение различных трансплантатов. В литературе имеются данные об изучении остеоинтеграции углеродных имплантов в эксперименте на нативном препарате. Однако данные об интеграции различных имплантов, их морфологические характеристики описаны недостаточно [6, 7]. Результаты применения разных вариантов замещения дефектов костной ткани при хирургическом лечении больных с хроническим остеомиелитом неоднозначны, поэтому поиск критериев оценки эффективности использования разных видов костной пластики остается актуальной задачей медицинской практики [8, 9]. Цель исследования: оценить степень остеоинтеграции различных остекондуктивных материалов в эксперименте на модели хронического остеомиелита при замещении дефекта диафиза кости. Морфологическая оценка остеоинтеграции различных имплантов при замещении дефектов длинных костей (экспериментальное исследование) // Гений ортопедии.
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