Коагуляционный гемостаз у крыс линии Вистар после кратковременной транзиторной ишемии головного мозга

Abstract

Hemocoagulation properties in rats following a single short-term transient cerebral ischemia were studied for 21 days of the postischemic period using the coarulometric methods involving the automatic optical determination of fibrin clot formation time in the blood plasma. On the 3rd day we observed the lowered activity of the external, internal and general hemocoagulation pathways: the activated partial thromboplastin time (aPTT), prothrombin time (PT) and thrombin time (TT) were increased, indicating the hypocoagulation in the hemostatic system. These changes were accompanied by the increase of the blood fibrinogen levels, probably due to the post-ischemic inflammation. Subsequently, the fibrinogen levels were increased again on the 14th day of the post-ischemic period. That increase was accompanied by the shortening of the aPTT, indicating hypercoagulation following the internal blood clotting pathway mechanisms. At the same day, we observed the increased TT, indicating the acceleration of the fibrin clot formation in the final stage of blood coagulation. Hypercoagulative changes in the hemostasis system developing along the internal and external hemocoagulation pathways were evidenced by the shortening of the aPTT and PT in comparison with the values in the control rats on the 21st day of the post-ischemic period. Thus, the risk of secondary thrombosis persists for 2-3 weeks after a single short-term transient cerebral ischemia.