Влияние вируса папилломы человека на фертильность и результаты программ вспомогательных репродуктивных технологий

Abstract

Aim. Тo summarize the information of contemporary literature on the effect of HPV on fertility and the effectiveness of in vitro fertilization. Key points. Currently, there is a high prevalence of human papillomavirus among women of fertile age. However, compared to the sufficient knowledge of the oncogenic effects of the virus, the study of its effect on fertility requires further research and should get more attention due to the possible negative effects of HPV on pregnancy outcomes and ART results. Despite the contradictory information, there is a large amount of data on the ability of the virus to reduce sperm parameters, in particular sperm motility, the number of common gametes and the percentage of normal cells. The human papillomavirus can lead to blastocyst infection, reduce cell viability, disrupt placentation processes and subsequently lead to miscarriage. Surgical treatment of cervical pathology, the cause of which is the human papillomavirus, can also affect the results of pregnancy, and the risk of adverse outcomes directly depends on the radicality of the treatment. Conclusion. A link between HPV infection and impaired fertility is indeed present. The virus may affect the outcome of assisted reproductive technologies, but there is a great deal of conflicting data, highlighting the need for longer-term and larger studies to confirm these assumptions. Key words: human papillomavirus, in vitro fertilization, infertility, reproductive outcomes.