Эндогенные белки у детей грудного и раннего возраста с инфекцией мочевыводящих путей

Abstract

Study Objective: To find the diagnostic and pathogenetic significance of endogenous proteins in infants and toddlers with urinary tract infections (UTIs). Study Design: controlled clinical trial. Materials and Methods. We examined 34 children with UTIs aged 29 days to 2 years 11 months and 29 days. The control group included 20 healthy children. All subjects underwent measurement of serum hepatic and intestinal fatty acid-binding proteins (L-FABP, I-FABP), bacterial membrane permeability-increasing protein (BPI), as well as urinary I-FABP and zonulin using the enzyme-linked immunosorbent assay (ELISA) method. Study Results. Children with UTIs demonstrated significantly increased L-FABP and I-FABP levels vs. controls (798.89 ± 171.69 ng/mL vs. 175.86 ± 23.07 ng/mL; 92.37 ± 18.53 ng/mL vs. 19.21 ± 4.94 ng/mL, respectively, р < 0.05). BPI levels were also significantly higher (105.03 ± 38.18 ng/mL) in children with UTIs (р < 0.05). Urinary I-FABP concentration was significantly different from that in healthy children (0.11 ± 0.04 pg/mL vs. 0.039 ± 0.009 pg/mL, р < 0.05). Zonulin levels were also higher (3.15 ± 0.64 ng/mL vs. 0.12 ± 0.04 ng/mL, р < 0.01). Conclusion. The study allowed clarifying the pathogenic significance of increased intestine permeability in development of inflammations and identifying early markers of kidney nd urinary tract damages (L-FABP, I-FABP, BPI). Increased urinary I-FABP and zonulin levels can predict UTIs in infants and toddlers. Keywords: fatty acid-binding protein, membrane permeability-increasing protein, urinary tract infections.