Клинический опыт сочетанного применения ингибитора ангиогенеза афлиберцепта в лечении окклюзий ретинальных вен

Abstract

Purpose. To evaluate the effectiveness of the combined use of aflibercept and sulodexide in the treatment of macular edema (ME) in retinal vein occlusions (RVO). Material and methods. In the course of the study, 30 patients with MO with acute respiratory infections not exceeding 1.5 months ago were monitored. All underwent a standard ophthalmological examination, as well as optical coherence tomography with angiography function and electrophysiological studies. To assess the effectiveness of the combined use of aflibercept and sulodexide, all patients were divided into two groups. In patients of the first group (n = 16), the first intravitreal injection of aflibercept was supplemented with a course of sulodexide. The second group (n = 14) did not receive sulodexide. Results. The degree of improvement in the functions of the eye in patients of the first group, who received sulodexide in complex treatment, is due to the maximum level of restoration of retinal microcirculation in the macula due to an increase in the density of the capillary network in the superficial and deep vascular plexuses of the retina by more than 1.2 times and a decrease in the area of its foveal avascular zone 1.5 times in comparison with the initial state. Conclusion. The results of the study showed the high efficiency of the combined use of aflibercept and sulodexide in the treatment of MO in acute respiratory infections and allow us to recommend their use to improve hemomicrocirculation in the macular retina and increase visual functions. Keywords: macular edema, retinal vein occlusion, aflibercept, sulodexide.