Надання допомоги вагітним з істміко-цервікальною недостатністю за наявності нутритивної магнієвої недостатності

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The objective: of the study was the feasibility of further improvement of giving medical aid to pregnant women with cervical insufficiency, especially with nutritional magnesium deficiency. Materials and methods. The observation group was made of 50 women, in which in 13–16 week of pregnancy was diagnosed cervical insufficiency with presence of nutritional magnesium deficiency (amount of magnesium in blood <0.8 mmol/1). Level of magnesium ions in blood plasma of pregnant women was determined by colorimetric method using the analyzer Cobas 600c (501 module) and test systems Roche Diagnostics (Switzerland). The degree of CIn was determined with Shtembera scale. To correct magnesium deficiency was recommended Magnicum (PJSC «Kyiv Vitamin Factory») 2 tablets 2 times a day with meals. One tablet contains magnesium lactate dihydrate 470 mg, equivalent to 48 mg of magnesium and pyridoxine hydrochloride (vitamin B6) 5 mg. Results. One of the pathogenetic factors of CIn is nutritional magnesium deficiency in pregnant women. The results of correlation analysis showed the presence of a strong feedback (r =-0.83) between the concentration of magnesium ions in the blood serum of pregnant women and the inner diameter orifice of uterine cervix, and direct communication of medium strength (r=0.38) with a length of cervix. In studying of the correlations between blood parameters and morphometric parameters of cervix, was established a close relationship (r=0.78) between the length of cervix and parameters of vascular resistance in small arteries of cervix. At the same time, a weak correlation (r=-0.41) between the diameter of the inner orifice of cervix and hemodynamic parameters in small cervical arteries suggests that the change in diameter of the orifice is secondary in relation to disturbances in blood flow in small cervical arteries. Conclusion. Usage of Magnicumu provides effective correction of hypomagnesemia in pregnant, prevents the progression of CIn, reduces the frequency of miscarriage, reduces number of surgical cerclage of cervix, prevents complications during labor. Key words: Cervical insufficiency, nurtitional magnesium deficiency, Magnicum.