ВЛИЯНИЕ ЛОКАЛЬНОЙ АНТИГЕННОЙ СТИМУЛЯЦИИ МОЛОЧНОЙ ЖЕЛЕЗЫ НА ПОКАЗАТЕЛИ ИММУНОГЛОБУЛИНОВ В КРОВИ МЫШЕЙ

Abstract

Immunoglobulins are large glomerular proteins in blood plasma and are an important factor in humoral immunity. The concentration of immunoglobulins in blood plasma directly characterizes the body's ability to protect itself from foreign agents. Immunoglobulins play an extremely important role during pregnancy and lactation. Immunoglobulins of classes A, M and G enter the body of newborns with colostrum, thus realizing the biological mechanism of protecting newborns from infectious environmental influences. The shortage of immunological components of colostrum by young animals is associated with the widespread prevalence of mastitis in livestock complexes, since any form of mastitis adversely affects the composition and sanitary and hygienic parameters of milk. This problem can be solved by local antigenic stimulation of the mammary gland with various thermostable antigens corresponding to the main causative agents of mastitis. For example, the treatment of the mammary glands with staphylococcal vaccine a few days before giving birth allows not only to protect the lactating herd from mastitis of staphylococcal etiology, but also makes it possible to transfer anti-staphylococcal immunity to young animals in the process of drinking colostrum. In our study, while continuing to study the physiological mechanisms of the implementation of the local immune response of the mammary gland, we wanted to record changes in the humoral factors of immunity upon local stimulation of the mammary gland with staphylococcal vaccine in an experimental model of lactating mice. The main purpose of this study was to com pare the concentration of immunoglobulins of classes A, M and G in blood plasma in lactating mice immunized with staphylococcal vaccine and individuals that were not immunized. According to the results of the experiment, data were obtained showing that the concentration of immunoglobulins of all studied classes in immunized individuals significantly exceeds the concentration of the corresponding immunoglobulins in mice of the control group.