Abstract
Objective. To specify photochemical reactions, occurring in the blood of patients with non-ST elevation acute coronary syndrome (NSTE-ACS), followed by the study of the mechanisms of alterations of ultraviolet blood modification (UVBM) into biological reactions. Methods. We studied 90 blood samples from patients with NSTE-ACS, receiving complex treatment that included UVBM by mercury lamp radiation with blood taken from the ulnar vein (device "Nadezhda"), the course of treatment consisted of 5 procedures conducted daily. We compared absorption spectra of blood and erythrocytes, results of optical oximetry, spectrophotometry, data of general blood analysis before UVBM, during individual procedures and 20-30 minutes after the end of the course. Results. We have studied the effect of UVBM on patients with NSTE-ACS. Based on the results of spectral and clinical studies of blood, patterns of its photomodification under the influence of ultraviolet (UV) radiation were found. The spectra of blood absorption and blood oxygenation were evaluated in patients whose complex treatment included five courses of UVBM along with traditional drug therapy. It is noted that UV radiation leads to photomodification of blood, changes in the partial pressure of blood gases, changes in the level of oxyhemoglobin and the degree of hemoglobin oxygen saturation. UVBM is proven as an effective method of non-drug treatment of patients with NSTE-ACS. Conclusion. UVBM, influencing the oxygen metabolism in patients with NSTE-ACS, increases the oxygen capacity of the blood, reduces the oxygen demand by the tissues. Photoinduced changes in the degree of hemoglobin oxygen saturation are determined by the individual sensitivity of patients to UV radiation and can be controlled by venous blood oxygenation as the best way to individualize therapy.
Published Version
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